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Maddrey Discriminant Function Calculator

DF = 4.6 · (PT − control) + total bilirubin.

Compute the Maddrey Discriminant Function for severe alcoholic hepatitis from prothrombin time and total bilirubin: DF = 4.6 · (PT − control PT) + bilirubin (mg/dL). DF ≥ 32 indicates severe disease and possible benefit from corticosteroids.

Priya Venkatesan By Priya Venkatesan
Published Last reviewed 1 min read

Inputs

s
s
mg/dL

Results

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How to use this calculator

  1. Fill in the inputs above using the units you already have.
  2. Values update automatically as you type — no submit button needed.
  3. Hover any result row for the underlying formula and intermediate values.

Formula

DF = 4.6 · (PT − PT_control) + bilirubin

In depth

Compute the Maddrey Discriminant Function for severe alcoholic hepatitis from prothrombin time and total bilirubin: DF = 4.6 · (PT − control PT) + bilirubin (mg/dL). DF ≥ 32 indicates severe disease and possible benefit from corticosteroids.